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Evolution of a Human-Specific Tandem Repeat Associated with ALS

Meredith M. Course,Kathryn Gudsnuk,Samuel N. Smukowski,Kosuke Winston,Nitin Desai,Jay P. Ross,Arvis Sulovari,Cynthia Bourassa,Dan Spiegelman,Julien Couthouis,Chang-En Yu,Debby W. Tsuang,Suman Jayadev,Mark A. Kay,Aaron D. Gitler,Nicolas Dupre,Evan E. Eichler,Patrick A. Dion,Guy A. Rouleau,Paul N. Valdmanis

The American Journal of Human Genetics（2020）

Cited 38|Views88
Key words
amyotrophic lateral sclerosis, ALS,variable number tandem repeat, VNTR,long-read sequencing,neurodegenerative disease,noncoding RNA,tandem repeat expansion,modifier gene,evolutionary genetics,WD repeat domain 7, WDR7,ancient genomes
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