Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.

Rishi Arora,Chong Wai Liew,Tingjin Sherryl Soh, Dorcas Adobea Otoo,Cheah Chen Seh,Kimberley Yue,Shahul Nilar,Gang Wang,Fumiaki Yokokawa,Christian G. Noble,Yen Liang Chen,Pei-Yong Shi,Julien Lescar,Thomas M. Smith,Timothy E. Benson,Siew Pheng Lim

Journal of Virology（2020）

Cited 19|Views74

Key words

flaviviruses,dengue virus,nonstructural protein,high-throughput screening,inhibitor,binding site,SPR,X-ray crystallography,RNA-dependent RNA polymerase

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