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Process Development of a Second Generation Β-Amyloid-cleaving Enzyme Inhibitor—Improving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Bryan Li,Richard W. Barnhart,Amelie Dion,Steven Guinness, Alan Happe,Cheryl M. Hayward,Jeffrey Kohrt,Teresa Makowski,Mark Maloney,Jade D. Nelson,Asaad Nematalla,J. Christopher McWilliams,Zhihui Peng,Jeffrey Raggon,John Sagal,Gerald A. Weisenburger,Denghui Bao,Miguel Gonzalez,Jiangping Lu,Mark D. McLaws,Jian Tao,Baolin Wu

Organic Process Research & Development（2021）

Cited 4|Views16
Key words
BACE1,halogen-metal exchange,CSTR,continuous process,lithiothiazole
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