Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia

In this issue of Blood Cancer Discovery, Yan and colleagues discovered that mitochondria! deacylase, SIRT5, is required in AML cells to support mitochondrial oxidative phosphorylation, maintain redox homeostasis, and drive glutaminolysis. The new SIRT5 inhibitor, NRD167, can efficiently target SIRT5 in AMLs at micromolar range and may constitute a novel therapeutic approach to improve clinical outcomes of patients with AML.