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Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3clpro Substrate Degradome

Isabel Pablos,Yoan Machado,Hugo C. Ramos de Jesus,Yasir Mohamud,Reinhild Kappelhoff,Cecilia Lindskog,Marli Vlok,Peter A. Bell,Georgina S. Butler,Peter M. Grin,Quynh T. Cao,Jenny P. Nguyen,Nestor Solis,Srinivas Abbina,Wioletta Rut,John C. Vederas,Laszlo Szekely,Attila Szakos,Marcin Drag,Jayachandran N. Kizhakkedathu,Karen Mossman,Jeremy A. Hirota,Eric Jan,Honglin Luo,Arinjay Banerjee,Christopher M. Overall

Cell Reports（2021）

Cited 53|Views33
Key words
COVID-19,SARS-CoV-2 3CLpro,SARS-CoV-2 main protease,proteases,subsite specificity,active site structure,substrates,degradomics,proteomics,interactome
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