Pharmacodynamics and Molecular Correlates of Response to Glofitamab in Relapsed/refractory Non-Hodgkin Lymphoma

Ann-Marie E. Broeske,Koorosh Korfi,Anton Belousov,Sabine Wilson,Chia-Huey Ooi,Christopher R. Bolen,Marta Canamero, Enrique Gomez Alcaide,Ian James,Emily C. Piccione,David J. Carlile,Natalie Dimier,Pablo Umana,Marina Bacac,Martin Weisser,Michael Dickinson

Blood advances（2022）

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摘要

Key Points Glofitamab induced dose-dependent induction of cytokines and T-cell margination, proliferation, and activation in peripheral blood. Tumor cell intrinsic factors (eg, TP53 and MYC signaling) are associated with resistance to glofitamab.

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