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Multiomic Profiling of Checkpoint Inhibitor-Treated Melanoma: Identifying Predictors of Response and Resistance, and Markers of Biological Discordance

Felicity Newell,Ines Pires da Silva,Peter A. Johansson,Alexander M. Menzies,James S. Wilmott,Venkateswar Addala,Matteo S. Carlino,Helen Rizos,Katia Nones,Jarem J. Edwards,Vanessa Lakis,Stephen H. Kazakoff,Pamela Mukhopadhyay,Peter M. Ferguson,Conrad Leonard,Lambros T. Koufariotis,Scott Wood,Christian U. Blank,John F. Thompson,Andrew J. Spillane,Robyn P. M. Saw,Kerwin F. Shannon,John Pearson,Graham J. Mann,Nicholas K. Hayward,Richard A. Scolyer,Nicola Waddell,Georgina Long

Cancer cell（2025）

Cited 68|Views36
Key words
whole genome sequencing,RNAseq,mutation burden,methylation,melanoma,interferon-γ,immunotherapy,anti-PD-1,anti-CTLA-4,resistance,treatment,targeted therapy
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