LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2

Skeletal muscle is a regulator of the body's energy expenditure and metabolism. Abnormal regulation of skeletal muscle-specific genes leads to various muscle diseases. Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in muscle growth and muscle atrophy. To explore the potential function of muscle-associated lncRNA, we analyzed our previous RNA-sequencing data and selected the lncRNA () as the research object. In this study, we report that is specifically enriched in skeletal muscle, and its transcriptional activity is positively regulated by transcription factor SP1. regulates myoblast proliferation and differentiation . , reduces intramuscular fat deposition, activates slow-twitch muscle phenotype, and inhibits muscle atrophy. Mechanistically, binds to sarcoplasmic/ER calcium ATPase 2 (SERCA2) protein to enhance SERCA2 protein stability and increase SERCA2 activity. Meanwhile, improves mitochondrial efficiency possibly through a SERCA2-mediated activation of the AMPK pathway. Our findings provide a strategy for using as an effective regulator for the treatment of muscle atrophy and energy metabolism.