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A Genome-Scale Gain-of-function CRISPR Screen in CD8 T Cells Identifies Proline Metabolism As a Means to Enhance CAR-T Therapy.

Lupeng Ye,Jonathan J. Park,Lei Peng,Quanjun Yang,Ryan D. Chow,Matthew B. Dong,Stanley Z. Lam,Jianjian Guo,Erting Tang,Yueqi Zhang,Guangchuan Wang,Xiaoyun Dai,Yaying Du,Hyunu R. Kim,Hanbing Cao,Youssef Errami,Paul Clark,Alexey Bersenev,Ruth R. Montgomery,Sidi Chen

Cell Metabolism（2022）

Cited 67|Views53
Key words
CAR-T,PRODH2,T cell GOF screen,T cell CRISPR activation screen,metabolism,proline metabolism,dead-guide RNA,antitumor efficacy,mitochondria
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