Discovery of CC-99677, a Selective Targeted Covalent MAPKAPK2 (MK2) Inhibitor for Autoimmune Disorders

John Malona,Claudio Chuaqui, Boris M. Seletsky,Lisa Beebe,Susan Cantin,Daniel Van Kalken,Kelly Fahnoe,Zhigang Wang, Beth Browning, Hilary Szabo, Louise A. Koopman,Tamas Oravecz,Joseph J. Mcdonald,Francisco Ramirez-valle,Rajula Gaur,Kofi A. Mensah, Michael Thoams,Jamie N. Connarn, Haiqing Hu, Matthew D. Alexander,Alan F. Corin

Translational research（2022）

Cited 9|Views33

Key words

AE,ARE,AS,ATF2,AUC,BE,C140,CAMKK2,CD,Cmax,CV,DYRK,EC50,ERK5,FGFR4,FIH,HSP27,HuR,IC50,IS,LC,LRRK2,MALDI,MKP-1,MCP-1,MK2,MK2i,MK3,MS,MSD,MSK1,MS/MS,MTHD,NOMID,pHSP27,PK,PMA,PoA,PRAK,QC,RA,SILAC,SMaSh,SNAr,STK40,TCI,Tmax,TTP

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