Using a Peptide-Based Mass Spectrometry Approach to Quantitate Proteolysis of an Intact Heterogeneous Procollagen Substrate by BMP1 for Antagonistic Antibody Screening

Wu Cong,Cook Ryan,Wu Ping,Srikumar Neha, Chee Elin,Sawyer William S.,Wang Hua,Hazen Meredith,Hotzel Isidro,N’Diaye Elsa-Noah,Ding Ning,Liu Yichin,Tran John C.,Ye Zhengmao

Analytical and Bioanalytical Chemistry（2022）

Cited 0|Views38

Key words

Antibody antagonist,High-throughput screening,Fibrotic diseases,BMP1,Procollagen,Heterogeneous protein substrate,Triple quadrupole mass spectrometry,Signature peptide,Lys-C

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