Fragment-based Design of Α-Cyanoacrylates and Α-Cyanoacrylamides Targeting Dengue and Zika NS2B/NS3 Proteases

Gabriel Gomes Vilela,Wadja Feitosa dos Santos Silva, Vitoria de Melo Batista,Leandro Rocha Silva,Hannah Maus,Stefan Josef Hammerschmidt,Clara Andrezza Crisostomo Bezerra Costa,Orlando Francisco da Silva Moura,Johnnatan Duarte de Freitas,Grazielle Lobo Coelho,Julia de Andrade Brandao,Leticia Anderson,Enio Jose Bassi,Joao Xavier De Araujo-Junior,Tanja Schirmeister,Edeildo Ferreira da Silva-Junior

New journal of chemistry（2022）

引用 3|浏览15

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摘要

In this study, a virtual FBDD approach was used to develop new cyanoacrylamides with activity against DENV and ZIKV NS2B/NS3 proteases, in which the best candidate was able to reduce the virus RNA copies.

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