Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems.

Miguel A. Matilla,Rita E. Monson,Annabel Murphy,Muriel Schicketanz,Alison Rawlinson,Caia Duncan,Juan Mata,Finian Leeper,George P. C. Salmond

mBio（2022）

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摘要

Fungal infections represent a major clinical, agricultural, and food security threat worldwide, which is accentuated due to the difficult treatment of these infections. Microorganisms represent a prolific source of antibiotics, and current data support that this enormous biosynthetic potential has been scarcely explored.

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Dickeya solani,acyl-homoserine lactone,agriculture and global food security,antibiotics,antifungal agents,gene regulation,horizontal gene transfer,hybrid polyketide,nonribosomal peptide,phytopathogens,post-transcriptional control mechanisms,quorum sensing,secondary metabolism

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