The Hierarchical Sequence Requirements of the H1 Subtype-Specific Noncoding Regions of Influenza A Virus

Minglei Pan,Wenyu Zhang,Yue Xiao,Yuerong Lai,Mengmeng Cao,Jianwei Wang,Tao Deng

Microbiology spectrum（2022）

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摘要

The segment-specific and subtype-specific nonconserved noncoding regions (ssNCRs) at both 3′ and 5′ ends of viral RNA segments of influenza A virus are largely conserved among the same segments of different viruses. However, the function-related sequence requirements of these ssNCRs remain unclear.

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关键词

influenza A virus,segment-specific and subtype-specific noncoding nucleotides,virus random nucleotide selection assay,sequence requirements,promoter-proximal nucleotides

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