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Mutation-induced LZTR1 Polymerization Provokes Cardiac Pathology in Recessive Noonan Syndrome

Alexandra Viktoria Busley,Oscar Gutierrez-Gutierrez,Elke Hammer, Fabian Koitka,Amin Mirzaiebadizi,Martin Steinegger,Constantin Pape, Linda Boehmer, Henning Schroeder,Mandy Kleinsorge,Melanie Engler,Ion Cristian Cirstea,Lothar Gremer,Dieter Willbold,Janine Altmuller,Felix Marbach,Gerd Hasenfuss,Wolfram-Hubertus Zimmermann,Mohammad Reza Ahmadian,Bernd Wollnik,Lukas Cyganek

Cell reports（2024）

Cited 0|Views47
Key words
cardiomyocytes,hypertrophic cardiomyopathy,iPSCs,LZTR1,Noonan syndrome,disease modeling,CRISPR/Cas9,RAS-MAPK signaling,protein polymerization
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