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Bispecific Antibody CAP256.J3LS Targets V2-apex and CD4-binding Sites with High Breadth and Potency

Baoshan Zhang,Jason Gorman,Young D. Kwon,Amarendra Pegu,Cara W. Chao,Tracy Liu,Mangaiarkarasi Asokan,Michael F. Bender,Tatsiana Bylund, Leland Damron,Deepika Gollapudi,Paula Lei,Yile Li,Cuiping Liu,Mark K. Louder,Krisha McKee,Adam S. Olia,Reda Rawi,Arne Schon,Shuishu Wang,Eun Sung Yang,Yongping Yang,Kevin Carlton,Nicole A. Doria-Rose,Lawrence Shapiro,Michael S. Seaman,John R. Mascola,Peter D. Kwong

mAbs（2023）

引用 6|浏览0
关键词
Antibody half-life,antibody improvement,bispecific antibody,CAP256-VRC26.25,CD4-binding site,cryo-electron microscopy,HIV-1,J3 nanobody,V2 apex
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