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Ternary Complex Dissociation Kinetics Contribute to Mutant-Selective EGFR Degradation

Scott C. Rosenberg,Frances Shanahan,Sayumi Yamazoe,Marc Kschonsak,Yi J. Zeng,James Lee,Emile Plise,Ivana Yen,Christopher M. Rose,John G. Quinn,Lewis J. Gazzard,Benjamin T. Walters,Donald S. Kirkpatrick,Steven T. Staben,Scott A. Foster,Shiva Malek

CELL CHEMICAL BIOLOGY（2023）

Cited 6|Views38

Key words

EGFR,degrader,inhibitor,VHL,PROTAC,chemical biology

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