Improving the in Vivo QTc Assay: the Value of Implementing Best Practices to Support an Integrated Nonclinical-Clinical QTc Risk Assessment and TQT Substitute

Hugo M. Vargas,Eric I. Rossman,Todd A. Wisialowski,Jill Nichols,Michael K. Pugsley,Brian Roche,Gary A. Gintant,Andrea Greiter-Wilke,Robert B. Kleiman,Jean-Pierre Valentin,Derek J. Leishman

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS（2023）

Cited 11|Views19

Key words

QT prolongation,In vivo cardiovascular telemetry,hERG,Ventricular repolarization,Cardiovascular safety,ICH S7B,ICH E14,S7BQ&As,Integrated risk assessment

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined