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A Rapid Intracellular Enrichment of Alkylating Payload is Essential for Melphalan Flufenamide Potency and Mechanism of Action

Ulrica Westermark,Yumei Diao, Karl-Johan Fasth, Mathias Farnegardh,Katarina Farnegardh,Kristin Hammer,Fredrik Lehmann,Klara Acs,Stefan Svensson Gelius

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS（2023）

Cited 0|Views13
Key words
Melflufen,yH2AX kinetic,Melflufen's stereoisomers,Intracellular uptake,Apoptosis
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