Figure S3 from A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow

Supplementary-Figure 3 Correlations between MSCs, CFU-f and homing (A) The percentage of detected MSCs in vivo in control mice and after PTH/ZA treatment correlates negatively with the number of detected tumor cells in the bone marrow, n=40, Pearson''s correlation r=-0.59. (B) The percentage of detected MSCs in vivo in control mice and after PTH/ZA treatment correlates positively with the number of CFU-fs in vitro. (n=27; Pearson correlation r=0.57). (C) In the absence of tumor cells, the combination of PTH/ZA diminishes the MSC subpopulation. Please compare to Fig. 1G obtained in the presence of cancer cells, n=9/12/9/9 in three experiments. Apoptosis after PTH/ZA treatment (D) Apoptosis in CD45- Ter119- CD31+ cells increased after treatment with PTH/ZA and ZA alone, whereas apoptosis in CD45- Ter119- CD146+ cells only increased in the PTH/ZA-treated group, n=10/12/7/7 in 3 experiments.