Evaluation of Relationship Between Endometrial Polyp and Insulin Resistance: A Case-Control Study

Objectives: Recently insulin resistance (IR) has increasingly attracted attention for its role in promoting endometrial proliferation.This study was conducted to investigate the correlation between endometrial polyps (EP) and IR, and the risk factors.Material and Methods: Retrospective analysis was carried out among patients who underwent hysteroscopy in gynecology and obstetrics department of Macau Kiangwu Hospital during October 2021 and December 2022.According to the pathological results of endometrium, subjects were divided into EP group and control group (normal endometrium).The clinical data and insulin resistance related indicators were compared.Results: 134 patients with EP and 98 control patients were included in this study.When compared with control patients, the percentage of irregular menstruation or amenorrhea was higher, the waist circumference was wider, the serum fasting insulin (FIN) level and insulin resistance index (HOMA-IR) were higher in EP patients, and the difference was statistically significant (p<0.05).Logistic multiple regression analysis showed that FIN, HOMA-IR, abdominal obesity and irregular menstrual cycle were risk factors for endometrial polyps.Conclusions: Patients with EP own some characteristics of IR, and IR may be related to the occurrence and development of EP, which should attract enough attention from patients.Lifestyle adjusting, paying attention to menstruation, and adding insulin sensitizer when necessary are recommended.