Early Molecular Layer Interneuron Hyperactivity Triggers Purkinje Neuron Degeneration in SCA1.

Federica Pilotto,Christopher Douthwaite,Rim Diab,Xiaoqian Ye,Zahraa Al Qassab,Christoph Tietje,Meriem Mounassir,Adolfo Odriozola,Aishwarya Thapa,Ronald A. M. Buijsen, Sophie Lagache,Anne -Christine Uldry,Manfred Heller,Stefan Muller,Willeke M. C. van Roon-Mom,Benoit Zuber,Sabine Liebscher,Smita Saxena

Neuron（2023）

Cited 4|Views35

Key words

Purkinje neurons,molecular layer interneurons, spinocerebellar ataxia type 1,in vivo imaging,cerebellar circuit,iPSCs,GABAergic neurons,excitation/inhibition,chemogenetics,circuit modulation,mouse models,neurodegenerative disease

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