Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys
AAPS JOURNAL（2023）
Key words
bispecific antibody,covariate analysis,kallikrein 5/7,Netherton syndrome,pharmacokinetic/target engagement model
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