Alternative Therapy for Migraine Pain: A Qualitative Cohort Study

chemotaxis and actin cytoskeleton reorganization.To test whether Ccl27a is involved in I/R-related hypersensitivity, we performed a brachial artery occlusion with reperfusion in mice, followed by a second I/R 7 days later to develop prolonged painlike behaviors.We demonstrated that Ccl27a is enhanced in DRG neurons after repeated I/R and this regulates the infiltration of CD3+ T cells to the muscles.AAV-mediated inhibition of CcL27a in sensory afferents not only blocked T cell recruitment to the injured muscles, but also inhibited spontaneous pain-like behaviors after repeated I/ R.This data may support a role for nociceptor derived CcL27a in immune responses in the muscle that regulate I/R-related hypersensitivity.Results could provide evidence for development of novel treatment strategies for patients with ischemic myalgia.R01NS113965; R01NS105715.