Deletion of the Inhibitory Co-Receptor CTLA-4 Enhances and Invigorates Chimeric Antigen Receptor T Cells

Sangya Agarwal,M. Angela Aznar,Andrew J. Rech,Charly R. Good,Shunichiro Kuramitsu,Tong Da,Mercy Gohil,Linhui Chen, Seok-Jae Albert Hong,Pranali Ravikumar,Austin K. Rennels,January Salas-Mckee,Weimin Kong,Marco Ruella,Megan M. Davis,Gabriela Plesa,Joseph A. Fraietta,David L. Porter,Regina M. Young,Carl H. June

Immunity（2023）

Cited 23|Views43

Key words

CAR T cells,acute lymphoblastic leukemia,chronic lymphocytic leukemia,CRISPR-Cas9,cancer immunotherapy,checkpoint blockade,PD-1,CTLA4,resistance,T cell exhaustion

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