Cleavage Site-Directed Antibodies Reveal the Prion Protein in Humans is Shed by ADAM10 at Y226 and Associates with Misfolded Protein Deposits in Neurodegenerative Diseases Feizhi Song , Valerija Kovac , Behnam Mohammadi , Jessica L. Littau , Franka Scharfenberg , Andreu Matamoros Angles , Ilaria Vanni , Mohsin Shafiq , Leonor Orge , Giovanna Galliciotti , Salma Djakkani , Luise Linsenmeier , Maja Černilec , Katrina Hartman , Sebastian Jung , Jörg Tatzelt , Julia E. Neumann , Markus Damme , Sarah K. Tschirner , Stefan F. Lichtenthaler , Franz L. Ricklefs , Thomas Sauvigny , Matthias Schmitz , Inga Zerr , Berta Puig , Eva Tolosa , Isidro Ferrer , Tim Magnus , Marjan S. Rupnik , Diego Sepulveda-Falla , Jakob Matschke , Lojze M. Šmid , Mara Bresjanac , Olivier Andreoletti , Susanne Krasemann , Simote T. Foliaki , Romolo Nonno , Christoph Becker-Pauly , Cecile Monzo , Carole Crozet , Cathryn L. Haigh , Markus Glatzel , Vladka Curin Serbec , Hermann C. Altmeppen Acta Neuropathologica（2024）
Key words
Alzheimer’s disease, Dementia, Extracellular vesicles, Neuroprotection, Prions, Proteolytic processing
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