Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Siddhartha P. Kar , Roger L. Milne , Ali Amin Al Olama , Kyriaki Michailidou , Jonathan Tyrer , Zsofia Kote‐Jarai , Kate Lawrenson , Sara Lindström , Susan J. Ramus , Deborah J. Thompson , Adam S. Kibel , Agnieszka Dansonka‐Mieszkowska , Agnieszka Michael , Aida Karina Dieffenbach , Aleksandra Gentry‐Maharaj , Alice S. Whittemore , Alicja Wolk , Alvaro N.A. Monteiro , Ana Paula Pereira Peixoto , Andrzej Kierzek , Angela Cox , Anja Rudolph , Anna González‐Neira , Anna H. Wu , Annika Lindblom , Anthony Swerdlow , Argyrios Ziogas , Arif B. Ekici , Barbara Burwinkel , Beth Y. Karlan , Børge G. Nordestgaard , Carl Blomqvist , Catherine M. Phelan , Catriona McLean , Celeste Leigh Pearce , Celine M. Vachon , Cezary Cybulski , Chavdar Slavov , Christa Stegmaier , Christiane Maier , Christine B. Ambrosone , Claus Høgdall , Craig C. Teerlink , Daehee Kang , Daniel C. Tessier , Daniel J. Schaid , Daniel O. Stram , Daniel W. Cramer , David E. Neal , Diana Eccles , Dieter Flesch‐Janys , Digna R. Velez Edwards , Dominika Wokozorczyk , Douglas A. Levine , Drakoulis Yannoukakos , Elinor J. Sawyer , Elisa V. Bandera , Elizabeth M. Poole , Ellen L. Goode , Э. К. Хуснутдинова , Estrid Høgdall , Fengju Song , Fiona Bruinsma , Florian Heitz , Francesmary Modugno , Freddie C. Hamdy , Fredrik Wiklund , Graham G. Giles , Håkan Olsson , Hans Wildiers , Hans-Ulrich Ulmer , Hardev Pandha , Harvey A. Risch , Hatef Darabi , Helga B. Salvesen , Heli Nevanlinna , Henrik Grönberg , Hermann Brenner , Hiltrud Brauch , Hoda Anton‐Culver , Honglin Song , Hui-Yi Lim , Iain A. McNeish , Ian Campbell , Ignace Vergote , Jacek Gronwald , Jan Lubiński , Janet L. Stanford , Javier Benı́tez , Jennifer A. Doherty , Jennifer B. Permuth , Jenny Chang‐Claude , Jenny Donovan , Joe Dennis , Joellen M. Schildkraut , Johanna Schleutker , John L. Hopper , Jolanta Kupryjańczyk , Jong Y. Park , Jonine D. Figueroa , Judith A. Clements , Julia A. Knight , Julian Peto , Julie M. Cunningham , Julio M. Pow‐Sang , Jyotsna Batra , Kamila Czene , Karen H. Lu , Kathleen Herkommer , Kay‐Tee Khaw , Keitaro Matsuo , Kenneth Muir , Kenneth Offitt , Kexin Chen , Kirsten B. Moysich , Kristiina Aittomäki , Kunle Odunsi , Lambertus A. Kiemeney , Leon F.A.G. Massuger , Liesel M. FitzGerald , Linda S. Cook , Lisa Cannon-Albright , Maartje J. Hooning , Malcolm C. Pike , Manjeet K. Bolla , Manuel Luedeke , Manuel R. Teixeira , Marc T. Goodman , Marjanka K. Schmidt , Marjorie J. Riggan , Markus Aly , Mary Anne Rossing , Matthias W. Beckmann , Matthieu Moisse , Maureen Sanderson , Melissa C. Southey , Michael Jones , Michael Lush , Michelle A.T. Hildebrandt , Ming‐Feng Hou , Minouk J. Schoemaker , Montserrat García‐Closas , Natalia Bogdanova , Nazneen Rahman , Nhu D. Le , Nick Orr , Nicolas Wentzensen , Nora Pashayan , Paolo Peterlongo , Pascal Guénel , Paul Brennan , Paula Loureiro Paulo , Penelope M. Webb , Per Broberg , Peter A. Fasching , Peter Devilee , Qin Wang , Qiuyin Cai , Qiyuan Li , Radka Kaneva , Ralf Bützow , Reidun Kristin Kopperud , Rita K. Schmutzler , Robert A. Stephenson , Robert J. MacInnis , Robert N. Hoover , Robert Winqvist , Roberta B. Ness , Ruth C. Travis , Sara Benlloch , Sara H. Olson , Shannon K. McDonnell , Shelley S. Tworoger , Sofia Maia , Sonja I. Berndt , Soo Chin Lee , Soo‐Hwang Teo , Stephen N. Thibodeau , Stig E. Bojesen , Susan M. Gapstur , Susanne K. Kjær , Tanja Pejović , Teuvo L.J. Tammela , Thilo Dörk , Thomas Brüning , Tiina Wahlfors , Tim Key , Todd L. Edwards , Usha Menon , Ute Hamann , Vanio Mitev , Veli‐Matti Kosma , Veronica Wendy Setiawan , Vessela N. Kristensen , Volker Arndt , Walther Vogel , Zheng Wang , Weiva Sieh , William J. Blot , Wojciech Kluźniak , Xiao‐Ou Shu , Yu‐Tang Gao , Fredrick Schumacher , Matthew L. Freedman , Andrew Berchuck , Alison M. Dunning , Jacques Simard , Christopher A. Haiman , Amanda B. Spurdle , Thomas A. Sellers , David J. Hunter , Brian E. Henderson , Peter Kraft , Stephen J. Chanock , Fergus J. Couch , Per Hall , Simon A. Gayther , Douglas F. Easton , Georgia Chenevix‐Trench , Rosalind Eeles , Paul D.P. Pharoah , Diether Lambrechts openalex
摘要
Supplementary Figure S1. LocusZoom regional association plots for the seven new cross-cancer loci that were > 1 Mb from known index SNPs. Supplementary Figure S2A-B. Box plots showing eQTL associations between (A) rs9375701 and L3MBTL3 in normal breast and prostate tissues and (B) rs8037137 and RCCD1 in normal breast and ovarian tissues. Supplementary Figure S3. Interactions between BCL2L11 and the 32 Biocarta "Death Pathway" genes. Interactions were identified using the GeneMania server. Circles contain gene names, lines represent interactions, and the color of the line indicates a specific type of interaction as listed in the legend.
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关键词
Pathway Analysis, Protein-Protein Interaction Networks, Gene Set Enrichment Analysis, Haplotype Mapping
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