PO-02-125 EVALUATION OF A GENOME-WIDE AND POLYGENIC RISK SCORE FOR THE PREDICTION OF ATRIAL FIBRILLATION RECURRENCE AFTER PULMONARY VEIN ISOLATION

Polygenic risk scores (PRS) were recently shown to be associated with preexisting atrial fibrillation (AF) and to be predictive of incident AF. Previous studies using limited PRS to predict recurrent AF following pulmonary vein isolation (PVI) showed inconsistent results. We sought to evaluate the association of PRS with AF recurrence following ablation using a genome-wide PRS combining >6 million single nucleotide polymorphisms (PRSAF) and, in a secondary analysis, a PRS limited to a locus involved in pulmonary vein development comprising the PITX2 gene (PRSPITX2).