Atypical Presenile Dementia

A clinico-pathological report is given of a case of dementia of frontal type with EEG changes, associated with a diffuse neuronal loss, subcortical gliosis and laminar spongiosis in the superficial part of the 2nd cortical layer. The authors discuss the cortical biopsy and the post-mortem findings in their case. They draw a comparison between their case an two conditions known as "progressive sub-cortical gliosis" and "Kraepelin's disease" which might be a single entity "atypical presenile dementia".