Harnessing Ceramic Hydroxyapatite As an Effective Polishing Strategy to Remove Product- and Process-related Impurities in Bispecific Antibody Purification

Nattha Ingavat,Xinhui Wang, Jia Min Liew,Farouq Bin Mahfut, Ka Pui But,Yee Jiun Kok,Xuezhi Bi,Yuansheng Yang, Kobayashi Shintaro, Maria Tsoumpra,Wei Zhang

BIORESOURCES AND BIOPROCESSING（2023）

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Key words

Bispecific antibody,Mixed-mode chromatography,Product- and process-related impurity removal,Chromatography-induced aggregation

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