A Meta-Analysis of Previous Falls and Subsequent Fracture Risk in Cohort Studies

Liesbeth Vandenput,Helena Johansson,Eugene V. McCloskey,Enwu Liu,Marian Schini,Kristina E. Åkesson,Fred A. Anderson,Rafael Azagra,Cecilie L. Bager,Charlotte Beaudart,Heike A. Bischoff-Ferrari,Emmanuel Biver,Olivier Bruyère,Jane A. Cauley,Jacqueline R. Center,Roland Chapurlat,Claus Christiansen,Cyrus Cooper,Carolyn J. Crandall,Steven R. Cummings,José A. P. da Silva,Bess Dawson-Hughes,Adolfo Diez-Perez,Alyssa B. Dufour,John A. Eisman,Petra J. M. Elders,Serge Ferrari,Yuki Fujita,Saeko Fujiwara,Claus-Christian Glüer,Inbal Goldshtein,David Goltzman,Vilmundur Gudnason,Jill Hall,Didier Hans,Mari Hoff,Rosemary J. Hollick,Martijn Huisman,Masayuki Iki,Sophia Ish-Shalom,Graeme Jones,Magnus K. Karlsson,Sundeep Khosla,Douglas P. Kiel,Woon-Puay Koh,Fjorda Koromani,Mark A. Kotowicz,Heikki Kröger,Timothy Kwok,Olivier Lamy,Arnulf Langhammer,Bagher Larijani,Kurt Lippuner,Fiona E. A. McGuigan,Dan Mellström,Thomas Merlijn,Tuan V. Nguyen,Anna Nordström,Peter Nordström,Terence W. O’Neill,Barbara Obermayer-Pietsch,Claes Ohlsson,Eric S. Orwoll,Julie A. Pasco,Fernando Rivadeneira,Anne-Marie Schott,Eric J. Shiroma,Kristin Siggeirsdottir,Eleanor M. Simonsick,Elisabeth Sornay-Rendu,Reijo Sund,Karin M. A. Swart,Pawel Szulc,Junko Tamaki,David J. Torgerson,Natasja M. van Schoor,Tjeerd P. van Staa,Joan Vila,Nicholas J. Wareham,Nicole C. Wright,Noriko Yoshimura,MCarola Zillikens,Marta Zwart,Nicholas C. Harvey,Mattias Lorentzon,William D. Leslie,John A. Kanis

Osteoporosis international（2024）

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摘要

The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. Previous falls are a well-documented risk factor for subsequent fracture but have not yet been incorporated into the FRAX algorithm. The aim of this study was to evaluate, in an international meta-analysis, the association between previous falls and subsequent fracture risk and its relation to sex, age, duration of follow-up, and bone mineral density (BMD). The resource comprised 906,359 women and men (66.9

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关键词

fracture risk,hip fracture,major osteoporotic fracture,meta-analysis,previous falls,risk factors

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