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Discovery of a Novel Androgen Receptor Antagonist, MEL-6, with Stereoselective Activity and Optimization of Its Metabolic Stability.

Christine Helsen,Konstantina Karypidou,Joice Thomas,Wout De Leger,Tien Nguyen,Steven Joniau,Arnout Voet,Wim Dehaen,Frank Claessens

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY（2024）

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关键词
Androgen receptor,Androgen receptor antagonist,Prostate cancer,Liver metabolism,Structural optimization
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