Development of a Multi-Modal Electrochemical Sensing (MES) Device for Real-Time Monitoring of Tumor Microenvironment Parameters in Cancer Immunotherapy

This paper introduces a multi-modal electrochemical-based sensing (MES) device for real-time monitoring of the biophysical profile of the tumor microenvironment (TME). The MES device integrates pH, glucose, and impedance sensors onto microneedles. Characterization results show promising sensor performance. MES device performance was illustrated in an in vivo rat subcutaneous tumor model. This device holds the potential for informing pre-clinical studies of cancer immunotherapy by providing real-time TME insights, which may inform the assessment of candidate therapeutic approaches. Future work will explore additional sensors and further validation, paving the way for its use in research and pre-clinical studies.