Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease Jack A. Terrett , Justin Q. Ly , Paula Katavolos , Catrin Hasselgren , Steven Laing , Fiona Zhong , Elisia Villemure , Martin Dery , Robin Larouche-Gauthier , Huifen Chen , Daniel G. Shore , Wyne P. Lee , Eric Suto , Kevin Johnson , Marjory Brooks , Alyssa Stablein , Francis Beaumier , Lea Constantineau-Forget , Chantal Grand-Maitre , Luce Lepissier , Stephane Ciblat , Claudio Sturino , Yong Chen , Baihua Hu , Justin Elstrott , Vineela Gandham , Victory Joseph , Helen Booler , Gary Cain , Carolina Chou , Aaron Fullerton , Michelle Lepherd , Shannon Stainton , Elizabeth Torres , Konnie Urban , Lanlan Yu , Yu Zhong , Linda Bao , Kang-Jye Chou , Jessica Lin , Wei Zhang , Hank La , Liling Liu , Teresa Mulder , Jun Chen , Tania Chernov-Rogan , Adam R. Johnson , David H. Hackos , Rebecca Leahey , Shannon D. Shields , Alessia Balestrini , Lorena Riol-Blanco , Brian S. Safina , Matthew Volgraf , Steven Magnuson , Satoko Kakiuchi-Kiyota JOURNAL OF MEDICINAL CHEMISTRY（2024）
Key words
TRP Channels, Calcium Signaling
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