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A Mitochondrial NADPH-cholesterol Axis Regulates Extracellular Vesicle Biogenesis to Support Hematopoietic Stem Cell Fate

Massimo Bonora,Claudia Morganti,Nick van Gastel,Kyoko Ito,Enrica Calura,Ilaria Zanolla,Letizia Ferroni,Yang Zhang,Yookyung Jung,Gabriele Sales,Paolo Martini,Takahisa Nakamura,Francesco Massimo Lasorsa,Toren Finkel,Charles P. Lin,Barbara Zavan,Paolo Pinton,Irene Georgakoudi,Chiara Romualdi,David T. Scadden,Keisuke Ito

Cell stem cell（2024）

Cited 2|Views42
Key words
hematopoietic stem cell,mitochondria,NADPH,cholesterol,fatty acid oxidation,fate determination,exosomes,extracellular vesicles,metabolism,HSC self-renewal
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