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Ex Vivo Activation of the GCN2 Pathway Metabolically Reprograms T Cells, Leading to Enhanced Adoptive Cell Therapy

Michael St. Paul,Samuel D. Saibil,Meghan Kates,Seongjun Han,Scott C. Lien,Rob C. Laister,Kebria Hezaveh,Andreas Kloetgen,Susanne Penny,Tingxi Guo,Carlos Garcia-Batres, Logan K. Smith,Douglas C. Chung,Alisha R. Elford,Azin Sayad,Devanand Pinto,Tak W. Mak,Naoto Hirano,Tracy McGaha,Pamela S. Ohashi

CELL REPORTS MEDICINE（2024）

Cited 0|Views36
Key words
GCN2,Halofuginone,adoptive Cell therapy,immunotherapy,CD8+ T cell,autophagy,immunometabolism,4-1BB
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