Reduced Cx43 Expression Induces Autophagy Through Activation of the AMPK-mTOR-ULK1 Signaling Pathway in the Common Bile Duct Ligation Rat Heart
Shock（2024）
Key words
Common bile duct ligation/CBDL,autophagy,AMPK-mtor-ulk1 signaling pathway,connexin43/cx43,myocardial injury,CBDL-common bile duct ligation,Cx43-connexin 43,AMPK-adenosine monophosphate-activated protein kinase,mTOR-mammalian target of rapamycin,ULK1-unc-51 like autophagy activating kinase 1,SD-Sprague-Dawley,NIH-National Institutes of Health,MCE-MedChemExpress,Rapa-Rapamycin,3-MA-3-Methyladenine,TBIL-total bilirubin,ALT-phenylalanine aminotransferase,AST-aspartate aminotransferase,LDH-lactic dehydrogenase,CK-MB-creatine kinase-MB,SV-stroke volume,CO-cardiac output,FS-fractional shortening,EF-ejection fraction,HR-heart rate,Com C-Compound C,AICAR-5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside,CCK-8-Cell Counting Kit-8,OD-optical density,TEM-transmission electron microscopy,ROS-reactive oxygen species,SOD-superoxide dismutase,GSH-PX-glutathione peroxidase,MDA-malondialdehyde,HE-hematoxylin and eosin staining,IHC-immunohistochemical analyses,IF-immunofluorescence staining
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