Predicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific Ipsc-Cms—a Proof-of-concept Study with Doxorubicin

Li Pang,Chengzhong Cai,Praful Aggarwal, Dong Wang,Vikrant Vijay,Prathyusha Bagam, Jacob Blamer,Andrea Matter,Amy Turner,Lijun Ren, Katy Papineau,Vinodh Srinivasasainagendra,Hemant K. Tiwari,Xi Yang,Laura Schnackenberg,William Mattes,Ulrich Broeckel

TOXICOLOGICAL SCIENCES（2024）

Cited 0|Views17

Key words

induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs),doxorubicin-induced cardiotoxicity (DIC),interindividual variability,in vitro cytotoxicity,transcriptome profiling

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