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Cancer SLC6A6-mediated Taurine Uptake Transactivates Immune Checkpoint Genes and Induces Exhaustion in CD8+ T Cells

Tianyu Cao,Wenyao Zhang,Qi Wang,Chen Wang, Wanqi Ma,Cangang Zhang,Minghui Ge,Miaomiao Tian,Jia Yu,Anjun Jiao,Liang Wang,Manjiao Liu,Pei Wang, Zhiyu Guo,Yun Zhou, Shuyi Chen,Wen Yin,Jing Yi,Hao Guo,Hua Han,Baojun Zhang,Kaichun Wu,Daiming Fan,Xin Wang,Yongzhan Nie,Yuanyuan Lu,Xiaodi Zhao

Cell（2024）

Cited 2|Views123
Key words
solute carrier,taurine,gastric cancer,T cell exhaustion,ER stress,transcription regulation,immune checkpoint,ATF4,chemoresistance,tumor recurrence and metastasis
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