Facile One-Pot Strategy for Radiopreprationof Radioiodinated Phenylpiracetam As a New Highly Selective Radiotracer for Brainimaging

The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizing agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO.