Figure 2 from Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium

Anirban Das,Nicholas R. Fernandez,Adrian Levine,Vanessa Bianchi,Lucie Stengs,Jiil Chung,Logine Negm, Jose Rafael Dimayacyac, Yuan Chang, Luiz Felipe Nobre,Ayse B. Ercan,Santiago Sánchez‐Ramírez,Sumedha Sudhaman,Melissa Edwards,Valérie Larouche,David Samuel,An Van Damme,David Gass,David S. Ziegler,Stefan Bielack,Carl Koschmann,Shayna Zelcer,Michal Yalon,Gadi Abede Campino,Tomasz Sarosiek,Kim E. Nichols,Rebecca Loret De Mola,Kevin Bielamowicz,Magnus Sabel, Charlotta A. Frojd,Matthew D. Wood,Jason Glover,Yi‐Yen Lee,Magimairajan Vanan,Jenny Adamski,Sébastien Perreault, Omar Chamdine,Magnus Aasved Hjort,Michal Zápotocký,Fernando Carceller,Erin Wright, Ivana Fedoráková, Alexander Lossos,Ryuma Tanaka,Michael Osborn,Deborah T. Blumenthal,Melyssa Aronson,Ute Bartels,Annie Huang,Vijay Ramaswamy,David Malkin,Adam Shlien,Anita Villani,Peter B. Dirks,Trevor J. Pugh,Gad Getz,Yosef E. Maruvka,Derek S. Tsang,Birgit Ertl‐Wagner,Cynthia Hawkins,Éric Bouffet,Daniel A. Morgenstern,Uri Tabori

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Abstract

Genomic features of patients with RRD-HGG treated with salvage therapies (n = 38). A, Onco-plot summarizing clinical and genomic features of patients who progressed on anti–PD-1 monotherapy and continued ICI treatment. B, Impact of TMB on survival. C, Impact of genomic MSI as measured by the tumor MMRDness score on survival (Methods).

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Biomarkers for Immunotherapy,Combination Therapies

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