DEI-02 SURVIVAL OUTCOMES BY RACE ACROSS DIFFERENT CONTINENTS FOLLOWING MINIMALLY INVASIVE SURGICAL TREATMENT FOR UPPER TRACT UROTHELIAL CARCINOMA: AN ANALYSIS OF THE ROBUUST REGISTRY

You have accessJournal of UrologyDiversity, Equity & Inclusion Forum (DEI01)1 May 2024DEI-02 SURVIVAL OUTCOMES BY RACE ACROSS DIFFERENT CONTINENTS FOLLOWING MINIMALLY INVASIVE SURGICAL TREATMENT FOR UPPER TRACT UROTHELIAL CARCINOMA: AN ANALYSIS OF THE ROBUUST REGISTRY Jason L. Zappia, Courtney Yong, Zhenjie Wu, Linhui Wang, Hooman Djaladat, Erika Wood, Alireza Ghoreifi, Firas Abdollah, Matthew Davis, Alex Stephens, Giuseppe Simone, Gabriele Tuderti, Mark Gonzalgo, Dinno Mendiola, Ithaar Derweesh, Sohail Dhanji, Kevin Hakimi, Vitaly Margulis, Jacob Taylor, Matteo Ferro, Marco Tozzi, Riccardo Autorino, Salvio Pandolfo, Reza Mehrazin, Benjamine Eilender, Francesco Porpiglia, Giovanni Busacca, Enrico Checcucci, Daniel Eun, Spencer Bell, and Chandru Sundaram Jason L. ZappiaJason L. Zappia , Courtney YongCourtney Yong , Zhenjie WuZhenjie Wu , Linhui WangLinhui Wang , Hooman DjaladatHooman Djaladat , Erika WoodErika Wood , Alireza GhoreifiAlireza Ghoreifi , Firas AbdollahFiras Abdollah , Matthew DavisMatthew Davis , Alex StephensAlex Stephens , Giuseppe SimoneGiuseppe Simone , Gabriele TudertiGabriele Tuderti , Mark GonzalgoMark Gonzalgo , Dinno MendiolaDinno Mendiola , Ithaar DerweeshIthaar Derweesh , Sohail DhanjiSohail Dhanji , Kevin HakimiKevin Hakimi , Vitaly MargulisVitaly Margulis , Jacob TaylorJacob Taylor , Matteo FerroMatteo Ferro , Marco TozziMarco Tozzi , Riccardo AutorinoRiccardo Autorino , Salvio PandolfoSalvio Pandolfo , Reza MehrazinReza Mehrazin , Benjamine EilenderBenjamine Eilender , Francesco PorpigliaFrancesco Porpiglia , Giovanni BusaccaGiovanni Busacca , Enrico CheccucciEnrico Checcucci , Daniel EunDaniel Eun , Spencer BellSpencer Bell , and Chandru SundaramChandru Sundaram View All Author Informationhttps://doi.org/10.1097/01.JU.0001008820.69436.91.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To compare survival outcomes across continents when stratified by race in patients with upper tract urothelial carcinoma (UTUC) following surgical treatment with radical nephroureterectomy (RNU). METHODS: A multicenter retrospective analysis using the ROBUUST (ROBotic surgery for Upper tract Urothelial cancer Study) registry identified patients undergoing surgical treatment for UTUC between 2015-2022 at 12 centers across the United States, Europe, and Asia. Patients were stratified by race and geographic location in which treatment took place. Univariate and multivariate analysis were performed. Recurrence-free survival (RFS) and overall survival (OS) were assessed using Kaplan-Meier analyses. RESULTS: 1446 patients were analyzed. Chemotherapy regimen, pathologic stage, and nodal staging were statistically different across all groups (Table 1). Blacks and Hispanics from the United States had significantly worse RFS relative to Blacks and Hispanics from Europe (p-value=0.0027 and p-value 0.0064, respectively) (Figure 1B and 1C). Asians from the United States had significantly worse RFS relative to Asians from Asia (p-value<0.001) (Figure 1D). On multivariate analysis adjuvant chemotherapy was associated with worse RFS among Blacks (10.21 [1.08, 96.33]; p=.0424) and Asians (HR 2.03 [1.23, 3.34]; p=.0058) within the United States when controlling for age, neoadjuvant and adjuvant chemotherapy, adjuvant bladder instillation and pathologic staging. There were no significant differences in RFS or OS between Whites from the United States and Europe (Figure 1A). CONCLUSIONS: Minority groups from Europe and Asia have better outcomes in regard to RFS following RNU for treatment of UTUC when compared to minority groups from the United States. These differences may be due to socioeconomic factors, treatment accessibility, cultural/ethnic differences in pursing healthcare, and differences in clinical management of UTUC across different continents. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e287 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Jason L. 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