166 Description of Radiological Growth Patterns in Screen-Detected Lung Cancers: the ASCENT Study Cohort

Lung cancer screening (LCS) with low-dose CT (LDCT) scans tracks tumour growth from small nodules to histologically proven cancers. The current growth model, based on the modified Schwartz formula, assumes an exponential growth pattern, but it is uncertain whether this applies to most screen-detected lung cancers (SDLC) across multiple time-points. The ASCENT study (NCT04204499) aims to characterise genomic landscape driving variations in tumour growth rates in surgically resected SDLC. Here, we describe and quantify radiological growth patterns of SDLCs enrolled in ASCENT