CAR T-cell Therapy in Mantle Cell Lymphoma with Secondary CNS Involvement - a Multicenter Experience.

Gulrayz Ahmed,Aseel Alsouqi,Aniko Szabo,Laura Samples,Mazyar Shadman,Farrukh T. Awan,Alexandra E. Rojek,Peter A. Riedell,Madiha Iqbal,Timothy S. Fenske,Mohamed A. Kharfan-Dabaja,Sawa Ito,Mehdi Hamadani

Blood advances（2024）

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摘要

Secondary central nervous system (CNS) involvement in Mantle cell lymphoma has poor outcomes, with limited data for efficacy of CAR-T therapy. This study reports encouraging response with reasonable safety profile, but risk of CNS relapse remains high in such patients.

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关键词

Mantle Cell Lymphoma,Secondary CNS Lymphoma,CAR-T,Non-Hodgkin Lymphoma,CRS,ICANS

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