Non-Glycosylated SARS-CoV-2 Omicron BA.5 Receptor Binding Domain (RBD) with a Native-like Conformation Induces a Robust Immune Response with Potent Neutralization in a Mouse Model

Rawiwan Wongnak,Subbaian Brindha,Mami Oba,Takahiro Yoshizue,Md. Din Islam,M. Monirul Islam,Hitoshi Takemae,Tetsuya Mizutani,Yutaka Kuroda

MOLECULES（2024）

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Key words

Omicron SARS-CoV-2,neutralization,non-glycosylation,molten globule state,native-like state,immunogenicity,E. coli-expression system,disulfide bonds,limited proteolysis

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