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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML

Lindsey G. DeRatt,Zhuming Zhang,Christine Pietsch,Justin S. Cisar,Xiaochun Zhang,Weixue Wang,Alexandra Tanner,Rosalie Matico,Paul Shaffer,Edgar Jacoby,Faraz Kazmi, Neetu Shukla,Tammy L. Bush,Aaron Patrick,Ulrike Philippar,Ricardo Attar,James P. Edwards,Scott D. Kuduk

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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