Association Between Mpmri Detected Tumor Apparent Diffusion Coefficient and 5-Year Biochemical Recurrence Risk after Radical Prostatectomy

To assess the ability of tumor apparent diffusion coefficient (ADC) values obtained from multiparametric magnetic resonance imaging (mpMRI) to predict the risk of 5-year biochemical recurrence (BCR) after radical prostatectomy (RP). This retrospective analysis included 1207 peripheral and 232 non-peripheral zone prostate cancer (PCa) patients who underwent mpMRI before RP (2012–2015), with the outcome of interest being 5-year BCR. ADC was evaluated as a continuous variable and as categories: low (< 850 µm2/s), intermediate (850–1100 µm2/s), and high (> 1100 µm2/s). Kaplan–Meier curves with log-rank testing of BCR-free survival, multivariable Cox proportional hazard regression models were formed to estimate the risk of BCR. Among the 1439 males with median age 63 (± 7) years, the median follow-up was 59 months, and 306 (25