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Endogenously Produced Itaconate Negatively Regulates Innate-Driven Cytokine Production and Drives Global Ubiquitination in Human Macrophages

Luke A. Bourner,Linda A. Chung, Haiyan Long,Anne F. McGettrick,Junpeng Xiao,Kenneth Roth,Jade D. Bailey, Marie Strickland,Bo Tan,Jason Cunningham, Barry Lutzke, James McGee, Francella J. Otero,David C. Gemperline, Lin Zhang,Ying C. Wang,Michael J. Chalmers, Chiao-Wen Yang,Jesus A. Gutierrez,Luke A. J. O'Neill,Frank C. Dorsey

Cell reports（2024）

Cited 0|Views7
Key words
immunometabolism,itaconate,IRG1,ACOD1,IRAK4,MYC,macrophage
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