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LAG-3 Sustains TOX Expression and Regulates the CD94/NKG2-Qa-1b Axis to Govern Exhausted CD8 T Cell NK Receptor Expression and Cytotoxicity

Shin Foong Ngiow,Sasikanth Manne,Yinghui Jane Huang, Tarek Azar,Zeyu Chen,Divij Mathew,Qingzhou Chen,Omar Khan,Jennifer E. Wu,Victor Alcalde,Ahron J. Flowers, Sean McClain,Amy E. Baxter,Makoto Kurachi,Junwei Shi,Alexander C. Huang,Josephine R. Giles,Arlene H. Sharpe,Dario A. A. Vignali,E. John Wherry

CELL（2024）

Cited 3|Views6

Key words

T cell exhaustion,LAG-3,PD-1,TOX,CD94,NKG2,NKG2A,Qa-1b,immunosurveillance,cancer

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