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COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis with Placebo and External Controls.

Kris V. Kowdley,Gideon M. Hirschfield,Charles Coombs,Elizabeth S. Malecha,Leona Bessonova, Jing Li,Nuvan Rathnayaka,George Mells,David E. Jones,Palak J. Trivedi,Bettina E. Hansen,Rachel Smith,James Wason,Shaun Hiu,Dorcas N. Kareithi,Andrew L. Mason,Christopher L. Bowlus,Kate Muller,Marco Carbone,Marina Berenguer,Piotr Milkiewicz,Femi Adekunle,Alejandra Villamil

AMERICAN JOURNAL OF GASTROENTEROLOGY（2025）

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Key words
confounding variables,functional unblinding,inverse probability of censoring weighting,treatment crossover
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